Research & Education

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Research & Education

The continued strategic development of academic rheumatology services at Tallaght University Hospital is key to the overall evolution of the specialty both within the framework of Trinity Health Ireland (THI) and at a national level. In addition to providing a base with which to attract talented researchers and clinicians, the existence of clinical and biomedical research facilities within the extended campus of THI will enable synergies in the areas of improved patient services, in research funding allocation, and future industrial partnerships. Most importantly, a continued drive for the highest standards of professional and academic excellence will foster an environment of innovation in the provision of world class patient-centred care.

The Department of Rheumatology at Tallaght University Hospital has a proven track record in both postgraduate research and in both undergraduate and post-graduate education. Through the stewardship of a successful post graduate MD programme, the Rheumatology Department has actively contributed to musculoskeletal ultrasound research, with the results of innovative research being presented at scientific meetings both nationally and internationally and published in high impact factor peer reviewed journals.

David Kane is Clinical Professor in Rheumatology at Trinity College Dublin. His principal clinical interests are musculoskeletal ultrasound and inflammatory arthritis. He is an international invited speaker and teacher in musculoskeletal ultrasound having published widely on this subject in peer reviewed journals. He is an active member of the EULAR Working group on Musculoskeletal Ultrasound since 2003, regular lecturer on the British Society for Rheumatology, EULAR and ACR musculoskeletal ultrasound courses, Honorary Treasurer of the Irish Society for Rheumatology, a current Board Member of Arthritis Ireland and previous Board member of the Irish Osteoporosis Society.

Prof. Ronan Mullan was recruited to Tallaght University Hospital as a Consultant Rheumatologist and Clinical Senior Lecturer in July 2012. He completed his undergraduate studies at Edinburgh University and a PhD in Translational Medicine Research at UCD Dublin and McGill University Montreal in 2008. In 2010 he was awarded a Paul Beeson Clinician Scientist Career Development Award by the American Federation for Aging Research and Atlantic Philanthropies to develop a Post-Doctoral research programme. His research interests include the molecular mechanisms of synovial inflammation in Rheumatoid Arthritis, and common inflammatory mechanisms of systemic autoimmune disease, metabolic syndrome and ageing.

Publications

Winchester R, Minevich G, Steshenko V, Kirby B, Kane D, Greenberg DA, FitzGerald O. HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. Arthritis Rheum. 2012 Apr;64(4):1134-44.

Mullan RH, Connolly M, McCormick J, Matthews C, Sullivan O, Kennedy A, FitzGerald O, Poole AR, Bresnihan B, Veale DJ, Fearon U. Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy. Arthritis Rheum. 2012 Apr;64(4):1035-45

Bowes J, Ho P, Flynn E, Ali F, Marzo-Ortega H, Coates LC, Warren RB, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, Fitzgerald O, Packham J, Morgan AW, Bruce IN, Barton A. Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort. Ann Rheum Dis. 2012 Feb 10.

Mandl P, Naredo E, Conaghan PG, D'Agostino MA, Wakefield RJ, Bachta A, Backhaus M, Hammer HB, Bruyn GA, Damjanov N, Filippucci E, Grassi W, Iagnocco A, Jousse-Joulin S, Kane D, Koski JM, Möller I, De Miguel E, Schmidt WA, Swen WA, Szkudlarek M, Terslev L, Ziswiler HR, Ostergaard M, Balint PV.Practice of ultrasound-guided arthrocentesis and joint injection, including training and implementation, in Europe: results of a survey of experts and scientific societies.Rheumatology (Oxford). 2012 Jan;51(1):184-90.

Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Bruce IN, Barton A. Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis. Ann Rheum Dis. 2011 Sep;70(9):1641-4.

Bowes J, Eyre S, Flynn E, Ho P, Salah S, Warren RB, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Griffiths CE, Bruce IN, Worthington J, Barton A. Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.Ann Rheum Dis. 2011 Jun;70(6):1016-9.

Gandjbakhch F, Terslev L, Joshua F, Wakefield RJ, Naredo E, D'Agostino MA; OMERACT Ultrasound Task Force. Ultrasound in the evaluation of enthesitis: status and perspectives. Arthritis Res Ther. 2011;13(6):R188.

Ahmed S, Kitchen J, Hamilton S, Brett F, Kane D. A case of polyarteritis nodosa limited to the right calf muscles, fascia, and skin: a case report. J Med Case Reports. 2011 Sep 12;5:450.

Naredo E, Wakefield RJ, Iagnocco A, Terslev L, Filippucci E, Gandjbakhch F, Aegerter P, Aydin S, Backhaus M, Balint PV, Bruyn GA, Collado P, Finzel S, Freeston JE, Gutierrez M, Joshua F, Jousse-Joulin S, Kane D, Keen HI, Moller I, Mandl P, Ohrndorf S, Pineda C, Schmidt WA, Szkudlarek M, Conaghan PG, D'Agostino MA.The OMERACT ultrasound task force--status and perspectives. J Rheumatol. 2011 Sep;38(9):2063-7.

Mandl P, Naredo E, Wakefield RJ, Conaghan PG, D'Agostino MA; OMERACT Ultrasound Task Force. A systematic literature review analysis of ultrasound joint count and scoring systems to assess synovitis in rheumatoid arthritis according to the OMERACT filter. J Rheumatol. 2011 Sep;38(9):2055-62.

Atchia I, Kane D, Birrell F.Comment on: steroid injection for hip osteoarthritis: efficacy under ultrasound guidance.Rheumatology (Oxford). 2011 Apr;50(4):812-3

Atchia I, Kane D, Reid M, Isaacs J, Birrell F. Efficacy of a Single Ultrasound Guided Injection for the Treatment of Hip Osteoarthritis. Ann Rheum Dis. 2011 Jan;70(1):110-6

Bowes J, Flynn E, Ho P, Aly B, Morgan AW, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Bruce IN, Barton A. Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. Ann Rheum Dis. 2010 Dec;69(12):2199-203.

Connolly M, Marrelli A, Blades M, McCormick J, Maderna P, Godson C, Mullan R, FitzGerald O, Bresnihan B, Pitzalis C, Veale DJ, Fearon U. Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model. J Immunol. 2010 Jun 1;184(11):6427-37.

Mullan RH, McCormick J, Connolly M, Bresnihan B, Veale DJ, Fearon U. A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A.Am J Pathol. 2010 Apr;176(4):1999-2008.

Gutierrez M, Filippucci E, De Angelis R, Filosa G, Kane D, Grassi W.

A sonographic spectrum of psoriatic arthritis: "the five targets".

Clin Rheumatol. 2010 Feb;29(2):133-42.

Naredo E, D'Agostino MA, Conaghan PG, Backhaus M, Balint P, Bruyn GA, Filippucci E, Grassi W, Hammer HB, Iagnocco A, Kane D, Koski JM, Szkudlarek M, Terslev L, Wakefield RJ, Ziswiler HR, Schmidt WA. Current state of musculoskeletal ultrasound training and implementation in Europe: results of a survey of experts and scientific societies. Rheumatology (Oxford). 2010 Dec;49(12):2438-43.

Kitchen J, Kane D. Non-steroidal anti-inflammatory drug prescriptions in hospital inpatients: are we assessing the risks? Ir J Med Sci. 2010 Sep;179(3):357-60.

Bruyn GA, Pineda C, Hernandez-Diaz C, Ventura-Rios L, Moya C, Garrido J, Groen H, Pena A, Espinosa R, Möller I, Filippucci E, Iagnocco A, Balint PV, Kane D, D'Agostino MA, Angulo M, Ponte R, Fernandez-Gallardo JM, Naredo E. Validity of ultrasonography and measures of adult shoulder function and reliability of ultrasonography in detecting shoulder synovitis in patients with rheumatoid arthritis using magnetic resonance imaging as a gold standard. Arthritis Care Res 2010 Aug;62(8):1079-86.

Cunnington J, Marshall N, Hide G, Bracewell C, Isaacs J, Platt P, Kane D. A randomized, double-blind, controlled study of ultrasound-guided corticosteroid injection into the joint of patients with inflammatory arthritis. Arthritis Rheum. 2010 Jul;62(7):1862-9.

Gutierrez M, Filippucci E, De Angelis R, Filosa G, Kane D, Grassi W. A sonographic spectrum of psoriatic arthritis: "the five targets". Clin Rheumatol. 2010 Feb;29(2):133-42. Epub 2009 Oct 24.

Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U.Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies. Arthritis Res Ther. 2009;11(4):R113. Epub 2009 Jul 23.

French HP, Cusack T, Brennan A, White B, Gilsenan C, Fitzpatrick M, O'Connell P, Kane D, Fitzgerald O, McCarthy GM.

Exercise and manual physiotherapy arthritis research trial (EMPART): a multicentre randomised controlled trial.

BMC Musculoskelet Disord. 2009 Jan 19;10:9.

D'Agostino MA, Conaghan PG, Naredo E, Aegerter P, Iagnocco A, Freeston JE, Filippucci E, Moller I, Pineda C, Joshua F, Backhaus M, Keen HI, Kaeley G, Ziswiler HR, Schmidt WA, Balint PV, Bruyn GA, Jousse-Joulin S, Kane D, Moller I, Szkudlarek M, Terslev L, Wakefield RJ. The OMERACT ultrasound task force -- Advances and priorities. J Rheumatol. 2009 Aug;36(8):1829-32.

Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS, Murphy EP. Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57.

Taggart AJ, Wright SA, Ball E, Kane D, Wright G. The Belfast musculoskeletal ultrasound course. Rheumatology 2009 Sep;48(9):1073-6.

French HP, Cusack T, Brennan A, White B, Gilsenan C, Fitzpatrick M, O'Connell P, Kane D, Fitzgerald O, McCarthy GM. Exercise and manual physiotherapy arthritis research trial (EMPART): a multicentre randomised controlled trial. BMC Musculoskelet Disord. 2009 Jan 19;10:9

Bruyn GA, Naredo E, Möller I, Moragues C, Garrido J, de Bock GH, d'Agostino MA, Filippucci E, Iagnocco A, Backhaus M, Swen WA, Balint P, Pineda C, Milutinovic S, Kane D, Kaeley G, Narvaez FJ, Wakefield RJ, Narvaez JA, de Augustin J, Schmidt WA. Reliability of ultrasonography in detecting shoulder disease in patients with rheumatoid arthritis. Ann Rheum Dis. 2009 Mar;68(3):357-61.

Veerappan SG, Moinuddin G, Kennedy M, O'Morain CA, Kane D. Early diagnosis of bilateral sub-deltoid bursitis using clinic-based ultrasonography in a patient receiving infliximab therapy for ulcerative pouchitis. Ir J Med Sci. 2008

Keen HI, Lavie F, Wakefield RJ, D'Agostino MA, Berner Hammer H, Hensor EM, Pendleton A, Kane D, Guerini H, Schueller-Weidekamm C, Kortekaas MC, Birrell F, Kloppenburg M, Stamm T, Watt I, Smolen JS, Maheu E, Dougados M, Conaghan PG. The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis. Ann Rheum Dis 2008 May;67(5):651-5

Balint PV, Mandl P,Kane D. "All that glistens is not gold"--separating artefacts from true Doppler signals in rheumatological ultrasound. Ann Rheum Dis. 2008;67:141-2

Mullan RH, Matthews C, Bresnihan B, FitzGerald O, King L, Poole AR, Fearon U, Veale DJ.Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy. Arthritis Rheum. 2007 Sep;56(9):2919-28.

Naredo E, Bijlsma JW, Conaghan PG, Acebes C, Balint P, Hammer HB, Bruyn GA, Collado P, D'Agostino MA, de Agustin JJ, de Miguel E, Filippucci E, Grassi W, Iagnocco A, Kane D, Koski JM, Manger B, Mayordomo L, Möller I, Moragues C, Rejón E, Szkudlarek M, Terslev L, Uson J, Wakefield RJ, Schmidt WA. Recommendations for the content and conduct of EULAR Musculoskeletal Ultrasound Courses. Ann Rheum Dis. 2008; 67(7):1017-22

Atchia I, Birrell F, Kane D. A modular, flexible training strategy to achieve competence in diagnostic and interventional musculoskeletal ultrasound in patients with hip osteoarthritis.Rheumatology. 2007;46(10):1583-6.

Cunnington J, Platt P, Raftery G, Kane D (2007) Attitudes of United Kingdom rheumatologists to musculoskeletal ultrasound practice and training. Ann Rheum Dis 2007;66:1381-3

Joshua F, Lassere M, Bruyn GA, Szkudlarek M, Naredo E, Schmidt WA, Balint P, Filippucci E, Backhaus M, Iagnocco A, Scheel AK, Kane D, Grassi W, Conaghan PG, Wakefield RJ, D'Agostino MA. Summary findings of a systematic review of the ultrasound assessment of synovitis. J Rheumatol 2007;34:839-847

Meenagh G, Filippucci E, Kane D, Taggart A, Grassi W. Ultrasonography in rheumatology: developing its potential in clinical practice and research. Rheumatology 2007; 46:3-5

Raftery G, Griffiths B, Kay L, Kane D.  Chronic viral hepatitis and TNF-alpha blockade. Rheumatology 2007; 46:1381

Raftery G, Hide G, Kane D. Comparison of musculoskeletal ultrasound practices of a rheumatologist and a radiologist. Rheumatology 2007 46:519-522

Sattar N, Crompton P, Cherry L, Kane D, Lowe G, McInnes IB. Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: a double-blind, placebo-controlled study. Arthritis Rheum 2007; 56:831-839

Wakefield RJ, D'Agostino MA, Iagnocco A, Filippucci E, Backhaus M, Scheel AK, Joshua F, Naredo E, Schmidt WA, Grassi W, Moller I, Pineda C, Klauser A, Szkudlarek M, Terslev L, Balint P, Bruyn GA, Swen WA, Jousse-Joulin S, Kane D, Koski JM, O'Connor P, Milutinovic S, Conaghan PG. The OMERACT Ultrasound Group: status of current activities and research directions. J Rheumatol 2007 34:848-851

Fearon U, Mullan RH, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ.Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum. 2006 Oct;54(10):3152-62.

Markham T, Mullan RH, Golden-Mason L, Rogers S, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ.Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy.J Am Acad Dermatol. 2006 Jun;54(6):1003-12.

Mullan RH, Bresnihan B, Golden-Mason L, Markham T, O'Hara R, FitzGerald O, Veale DJ, Fearon U.Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway.      Arthritis Rheum. 2006 Jan;54(1):105-14.

Markham T, Mathews C, Rogers S, Mullan RH, Bresnihan B, Fitzgerald O, Veale DJ, Fearon U.Downregulation of the inhibitor of apoptosis protein survivin in keratinocytes and endothelial cells in psoriasis skin following infliximab therapy.Br J Dermatol. 2006 Dec;155(6):1191-6.

Naredo E, Moller I, Moragues C, de Agustin JJ, Scheel AK, Grassi W, de Miguel E, Backhaus M, Balint P, Bruyn GA, D'Agostino MA, Filippucci E, Iagnocco A, Kane D, Koski JM, Mayordomo L, Schmidt WA, Swen WA, Szkudlarek M, Terslev L, Torp-Pedersen S, Uson J, Wakefield RJ, Werner C (2006) Interobserver reliability in musculoskeletal ultrasonography: results from a "Teach the Teachers" rheumatologist course. Ann Rheum Dis 65:14-19

Kane D, Bruyn G, Arnold E, Grassi W (2006) A rheumatologist's perspective on musculoskeletal ultrasound in rheumatology: comment on the editorial by Roemer et al. Arthritis Rheum 55:341-342

Mullan RH, Bresnihan B. Systemic Amyloidosis in the Rheumatic Diseases [Review]. ARC Topical Reviews. London. Number 6. June 2005

Cunnington J, Hide G, Kane D (2005) Training in musculoskeletal ultrasound by UK rheumatologists: when is now, but how? Rheumatology (Oxford) 44:1470-1472

Kane D (2005) The role of ultrasound in the diagnosis and management of psoriatic arthritis. Curr Rheumatol Rep 7:319-324

Kane D, Lockhart JC, Balint PV, Mann C, Ferrell WR, McInnes IB (2005) Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint). Ann Rheum Dis 64:325-327

Kane D, Pathare S (2005) Early psoriatic arthritis. Rheum Dis Clin North Am 31:641-657

Ralph JA, McEvoy AN, Kane D, Bresnihan B, FitzGerald O, Murphy EP (2005) Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor-mediated responses. J Immunol 175:555-565

Wakefield RJ, Balint PV, Szkudlarek M, Filippucci E, Backhaus M, D'Agostino MA, Sanchez EN, Iagnocco A, Schmidt WA, Bruyn GA, Kane D, O'Connor PJ, Manger B, Joshua F, Koski J, Grassi W, Lassere MN, Swen N, Kainberger F, Klauser A, Ostergaard M, Brown AK, Machold KP, Conaghan PG (2005) Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol 32:2485-2487

Kane D, Jensen LE, Grehan S, Whitehead AS, Bresnihan B, Fitzgerald O (2004) Quantitation of metalloproteinase gene expression in rheumatoid and psoriatic arthritis synovial tissue distal and proximal to the cartilage-pannus junction. J Rheumatol 31:1274-1280

Kane D, FitzGerald O (2004) Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective. Curr Rheumatol Rep 6:292-298

Kane D, Gogarty M, O'Leary J, Silva I, Bermingham N, Bresnihan B, Fitzgerald O (2004) Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum 50:3286-3295

Kane D, Grassi W, Sturrock R, Balint PV (2004) A brief history of musculoskeletal ultrasound: 'From bats and ships to babies and hips'. Rheumatology (Oxford) 43:931-933

Kane D, Grassi W, Sturrock R, Balint PV (2004) Musculoskeletal ultrasound--a state of the art review in rheumatology. Part 2: Clinical indications for musculoskeletal ultrasound in rheumatology. Rheumatology (Oxford) 43:829-838

Kane D, Balint PV, Gibney R, Bresnihan B, Sturrock RD (2004) Differential diagnosis of calf pain with musculoskeletal ultrasound imaging. Ann Rheum Dis 63:11-14

Kane D, Balint PV, Sturrock R, Grassi W (2004) Musculoskeletal ultrasound--a state of the art review in rheumatology. Part 1: Current controversies and issues in the development of musculoskeletal ultrasound in rheumatology. Rheumatology (Oxford) 43:823-828

Curran SA, FitzGerald OM, Costello PJ, Selby JM, Kane DJ, Bresnihan B, Winchester R (2004) Nucleotide sequencing of psoriatic arthritis tissue before and during methotrexate administration reveals a complex inflammatory T cell infiltrate with very few clones exhibiting features that suggest they drive the inflammatory process by recognizing autoantigens. J Immunol 172:1935-1944

Bresnihan B, Kane D (2004) Sonography and subclinical synovitis. Ann Rheum Dis 63:333-334

Mullan RH, Bresnihan B.Disease-modifying anti-rheumatic drug therapy and structural damage in early rheumatoid arthritis.Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S158-64. Review

Butler MW, Mullan RH, Schaffer KE, Crotty TB, Luke DA, Donnelly SC. Pulmonary cystic hydatid disease in Ireland. Ir J Med Sci. 2003 Oct-Dec;172(4):204-5.

Balding J, Kane D, Livingstone W, Mynett-Johnson L, Bresnihan B, Smith O, FitzGerald O (2003) Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. Arthritis Rheum 48:1408-1413

Balint PV, Kane D, Sturrock RD (2003) Case number 26: massive cholesterol crystal deposition: unusual location in rheumatoid arthritis. Ann Rheum Dis 62:512

Kane D, Barnes L, Fitzgerald O (2003) Topical corticosteroid treatment: systemic side-effects. Br J Dermatol 149:417

Kane D, FitzGerald O (2003) Re: The role of ultrasonography in the diagnosis and management of idiopathic plantar fasciitis. Rheumatology (Oxford) 42:486

Kane D, Roth J, Frosch M, Vogl T, Bresnihan B, FitzGerald O (2003) Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritis. Arthritis Rheum 48:1676-1685

Kane D, Stafford L, Bresnihan B, FitzGerald O (2003) A classification study of clinical subsets in an inception cohort of early psoriatic peripheral arthritis--'DIP or not DIP revisited'. Rheumatology (Oxford) 42:1469-1476

Kane D, Stafford L, Bresnihan B, FitzGerald O (2003) A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience. Rheumatology (Oxford) 42:1460-1468

Kane D, Balint PV, Sturrock RD (2003) Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis. J Rheumatol 30:966-971

Kane D, Balint PV, Wood F, Sturrock RD (2003) Early diagnosis of pyomyositis using clinic-based ultrasonography in a patient receiving infliximab therapy for Behcet's disease. Rheumatology (Oxford) 42:1564-1565

Haston JL, FitzGerald O, Kane D, Smith KD (2003) The influence of alpha1-acid glycoprotein on collagenase-3 activity in early rheumatoid arthritis. Biomed Chromatogr 17:361-364

Foell D, Kane D, Bresnihan B, Vogl T, Nacken W, Sorg C, Fitzgerald O, Roth J (2003) Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis. Rheumatology (Oxford) 42:1383-1389

Balint PV, Kane D, Hunter J, McInnes IB, Field M, Sturrock RD (2002) Ultrasound guided versus conventional joint and soft tissue fluid aspiration in rheumatology practice: a pilot study. J Rheumatol 29:2209-2213

Balint PV, Kane D, Wilson H, McInnes IB, Sturrock RD (2002) Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy. Ann Rheum Dis 61:905-910

Mullan RH, Ryan PF. Multiple site osteonecrosis in HIV infection. Rheumatology (Oxford). 2002 Oct;41(10):1200-2.

Bresnihan B, Roux-Lombard P, Murphy E, Kane D, FitzGerald O, Dayer JM (2002) Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis. Ann Rheum Dis 61:726-729

Haston JL, FitzGerald O, Kane D, Smith KD (2002) Preliminary observations on the influence of rheumatoid alpha-1-acid glycoprotein on collagen fibril formation. Biomed Chromatogr 16:332-342

Kane D, Sturrock R (2002) Diagnosing gouty arthritis. Practitioner 246:260-262, 264-265

Kane D, Veale DJ, FitzGerald O, Reece R (2002) Survey of arthroscopy performed by rheumatologists. Rheumatology (Oxford) 41:210-215

D Kane, T Greaney, B Bresnihan, M Shanahan, G Duffy, RG Gibney, O FitzGerald. The role of ultrasonography in the diagnosis and management of idiopathic plantar fasciitis. Rheumatology 2001;40:1002-9

PJ Costello, RJ Winchester, SA Curran, KS Peterson, DJ Kane, B Bresnihan, OM FitzGerald, Psoriatic Arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions that appear antigen driven. J Immunol 2001;166:1278-86

L Stafford, D Kane, E Murphy, T Duffy, M Lassere, PP Youssef, B Bresnihan, O FitzGerald. Psoriasis predicts a poor short-term outcome in patients with spondyloarthropathy. Arth Rheum 2001;45:485-493

P Balint, D Kane, R Sturrock. Modern patient management in rheumatology: interventional musculoskeletal ultrasonography. Osteoarthritis Cartilage 2001; 9:509-511

V Wright, L Nelson, C McMillan, C Perry, D Kane, M Field. Imperial Weight Measurements (Letter to the Editor) SMJ 2001;46:135

D Kane, O FitzGerald. Ultrasonography in psoriatic arthritis. J Rheum 2000;27:1564

P Costello, D Kane, S Curran, B Bresnihan, R Winchester, O FitzGerald. Psoriatic arthritis - a unified concept. Arth Rheum 2000;43:712-713

D Kane, T Greaney, B Bresnihan, RG Gibney, O FitzGerald. Ultrasonography in the diagnosis and management of psoriatic dactylitis. J Rheum 1999;26:1746-51

P Youssef, F Breedveld, B Bresnihan, N Cassidy, G Cunnane, P Emery, O FitzGerald, D. Kane, M Kraan, S Lindblad, R Reece, D Veale, PP Tak. Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples taken blindly by needle biopsy. Arthritis Rheum 1998;41:663-9

D Kane, F McSweeney, N Swan, B Bresnihan. Catastrophic antiphospholipid antibody syndrome in primary systemic sclerosis.  J Rheumatol 1998;25:810-3

D Kane, T Greaney, B Bresnihan, RG Gibney, O FitzGerald. Ultrasound-guided injection of recalcitrant plantar fasciitis. Ann Rheum Dis 1998; 57:383-4

N Flanagan, D Kane, E Sweeney, FM Mulcahy, L Barnes. Crusted Scarring Plaques on the Upper Body. Archives of Dermatology 1998;134:365-70

D Kane, O FitzGerald. Ultrasound-guided injection of plantar fasciitis. Ann Rheum Dis 1998;57:749-50

S Keating, D Kane, FM Mulcahy. Preventing AIDS. Journal of the Royal College of Physicians & Surgeons, Vol 26, No. 2, April 1997

O FitzGerald and D Kane. Clinical, Immunopathogenic and Therapeutic aspects of Psoriatic Arthritis. Current Opinion in Rheumatology 1997;9:295-301

D Kane, B. Bresnihan. Jaccoud's Arthropathy secondary to severe chronic eczema of the palms. Br J Rheumatol 1997;36:1339-40

C Williams, D Kane, G Duffy. Psoriatic Dactylitis-bone scintigraphic appearance. Clin Nucl Med 1997;22:853-4

D Kane, DJ McCarty. Tropical pyomyositis presenting as sciatica in Wicklow. IMJ 1997;90:155

D Kane, S Keating, S McCann, FM Mulcahy. The management of acute myeloid leukaemia (AML) in human immunodeficiency         virus (HIV) infection: a case report and review. International Journal of STD and AIDS 1997;8:272-274

JR Kerr, D Kane, B Crowley, N Leonard, S O' Briain, PV Coyle, FM Mulcahy. Parvovirus B19 infection in AIDS patients. International Journal of STD and AIDS 1997;8:184-6

S Dowling , D Kane, A Chua, S Keating, P Flood, PWN Keeling, FM Mulcahy. An Evaluation of Percutaneous Endoscopic Gastrostomy feeding in AIDS.

International Journal of STD and AIDS 1996; 7:106-109

D Kane, JM Murphy, S Keating, GF Wilson, FM Mulcahy. Renal ultrasonic findings in sulphadiazine-induced crystalluria. British Journal of Radiology 1996; 69:925-928

D Kane, C Bergin, S Keating, FM Mulcahy. Report on the 2nd International Congress on Drug Therapy in HIV infection (18-22 November 1994). JEADV 1994:14:27-8